Patients with a variant allele of CYP2C19 are 1. Administration of clopidogrel bisulfate with meals did not significantly modify the bioavailability of clopidogrel as assessed by the pharmacokinetics of the main circulating metabolite. In vitro and in vivo, clopidogrel undergoes rapid hydrolysis into its carboxylic acid derivative. In plasma and urine, the glucuronide of the carboxylic acid derivative is also observed. In March , the U. FDA added a boxed warning to Plavix alerting that the drug can be less effective in people unable to metabolize the drug to convert it to its active form.
Clopidogrel is one of the drugs metabolized by this enzyme. Especially tell your doctor if you take: Always talk to your doctor about whether you should take aspirin along with Plavix to treat your condition. Know the medicines you take. Keep a list of them to show your doctor or pharmacist when you get a new medicine. How should I take Plavix? Take Plavix exactly as your doctor tells you. Do not change your dose or stop taking Plavix without talking to your doctor first. Stopping Plavix may increase your risk of heart attack or stroke.
Take Plavix with aspirin as instructed by your doctor. If you miss a dose, take Plavix as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take the next dose at your regular time. Do not take 2 doses of Plavix at the same time unless your doctor tells you to.
If you take too much Plavix, call your doctor or go to the nearest emergency room right away. Talk with your doctor about stopping your Plavix before you have surgery. Your doctor may tell you to stop taking Plavix at least 5 days before you have surgery to avoid excessive bleeding during surgery. What are the possible side effects of Plavix? Consult your doctor for more details and about the risks of stopping early.
It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. What conditions does Clopidogrel treat? If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Although unlikely, serious bleeding in the stomach , gut, eyes , or brain may occur.
Also, clopidogrel can rarely cause a very serious blood disorder thrombotic thrombocytopenic purpura-TTP. Symptoms may appear any time after starting this medication. Get medical help right away if any of these symptoms occur: A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at List Clopidogrel side effects by likelihood and severity. Precautions Before taking clopidogrel , tell your doctor or pharmacist if you are allergic to it; or to similar antiplatelet drugs thienopyridines such as prasugrel ; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Canada residents can español a provincial poison control center. Plavix recent landmark español have proven 75mg importance of 2C19 genotyping in treatment using clopidogrel. What should I tell my doctor before taking Plavix? In vitro and in vivo, clopidogrel undergoes rapid hydrolysis into its carboxylic acid derivative. If you are currently taking aspirinplavix 75mg español, consult your doctor promptly and ask whether to continue or stop taking it with this medication for your specific condition aspirin and clopidogrel may be used in combination after a coronary stent procedure, or for some heart conditions. Ask your doctor or pharmacist about how much alcohol you may safely drink. If you miss a dose, take Plavix as soon as you remember. Ask your pharmacist about using these products safely. Promptly ask your doctor or pharmacist for more details. Take the next dose at your regular time. TTP is a blood clotting problem where blood clots form in blood vessels; and can happen anywhere in the body. Consult your pharmacist or local 75mg disposal company. Clopidogrel is one of the drugs metabolized by this plavix. In the US - Call your doctor for medical advice about side effects. Your doctor may tell you to stop taking Plavix at least 5 days before you have surgery to avoid excessive bleeding during surgery. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Combination with other drugs that affect blood clotting, such as aspirinheparins and thrombolyticsshowed plavix relevant interactions. If it is almost time for your next dose, skip the missed dose. The first step is an oxidation mediated mainly by CYP2C19, unlike the activation plavix the related drug prasugrel. Consult your pharmacist or local waste disposal company. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Only 75mg of the eight structures is plavix active antiplatelet drug. Otherwise, call a poison control center right español. In this trial the following rates of bleeding were observed, plavix 75mg español. To help you remember, take it at the same time each day. Before having surgery, tell your doctor español dentist about all the products you use including prescription drugsplavix 75mg español, nonprescription drugs, and herbal products. Get 75mg help right away if any of these symptoms occur: Stopping Plavix may 75mg your risk of heart attack or stroke, plavix 75mg español. Your doctor may do genetic tests to make sure Plavix is right for you. Clinical studies showed español this mechanism is irrelevant español practical purposes, plavix 75mg español. Take 75mg medication by plavix with or without food as directed by your doctor, usually once daily. Ask your pharmacist about using these products safely.
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